(£) GBP (Default)
  • ($) USD
  • (€) EUR
  • ($) AUD
  • ($) CAD
  • ($) NZD
Pharma Lab Global

15% off first order with code: 1storder

Pharma Lab Global
99%+ Quality Guaranteed
Pharma Lab Global
Pay by crypto get 10% discount
Pharma Lab Global
Shipping Protection
Pharma Lab Global
Fast Order Process

FOXO4-DRI Peptide Vial Denmark

FOXO4-DRI peptide, a cell-permeable and senolytic peptide, has shown promise in selectively removing senescent cells, which are associated with aging and age-related diseases. This peptide has been found to enhance tissue homeostasis, promote cartilage formation, and alleviate age-related testosterone secretion. Furthermore, studies have suggested that FOXO4-DRI may have potential benefits in promoting hair growth and fighting the effects of aging.

£202.79£209.59

SKU PLG: FOXO4-DRI vial Categories ,

Description

FOXO4-DRI Peptide Vial

FOXO4-D-Retro-Inverso is a modified form of the FOXO4 protein. The change extends the protein’s half-life and permits it to disrupt normal FOXO4 function. Denmark Studies have shown fewer senescent cells, better organ function, and younger tissue “biological age” as a result of using this protein. FOXO4-DRI peptide vial affects insulin, cell cycle, and oxidative stress signalling. This cell-penetrating peptide has been found to reverse the effects of ageing in animals.

Foxo4dri is a senolytic peptide that disrupts the p53 gene, causing apoptosis in ageing cells. This peptide may lead to a disease-free life with future investigation by reducing senescent cell formation.

What are senescent cells?

As we age, more cells become senescent, meaning they can no longer divide or support their tissues. These cells generate damaging chemical signals that cause nearby cells to be senescent. These cells are directly related to tissue damage, increased inflammation, and increased cancer risk. Further investigation has shown FOXO4 to inhibit the development of these harmful cells in animals, resulting in improved repair tissue quality. Moreover, it can even seek and eliminate these cells in test subjects’ bodies.


Specifications

Molecular Formula: C228H388N86O64
Sequence: H-LTLRKEPASEIAQSIL EAYSQNGWANRRSGGK RPPPRRRQRRKRG-OH
Molecular Weight: 5358.05 g/mol
Physical Appearance: White Lyophilised Solid
Form: Sterile Filtered White Lyophilized
Solubility: Water Soluble
Storage: Store at -20˚C

Size: 10mg


FOXO4-DRI Research Denmark

The foxo4 peptide was tested on naturally ageing animals and mice genetically designed to age quickly. After subjecting the mice to harsh chemotherapeutic treatments, the scientists found some intriguing clinical outcomes. On both sets of rats, FOXO4-DRI substantially mitigated chemotherapy-induced harm. The FOXO4 medication also restored liver and renal function and fur loss in the animal test subjects [1].

Neurodegenerative

Despite extensive current study the exact cause of age-related cognitive decline like Alzheimer’s isn’t fully understood. A change in proteasome activity has been linked to neurodegenerative conditions. Disrupted proteasome activity has been linked to Parkinson’s, Early-onset dementia, Huntington’s, and Prion diseases. However, it is unclear whether this is a primary cause or a secondary contributor [2].

Also, ALS (Lou Gehrig’s disease) affects proteasome function. The discovery that extracellular FOXO protein may help treat or prevent neurodegenerative disorders has prompted researchers to explore the idea that exogenous FOXO protein may be helpful. A modified FOXO protein, FOXO4-DRI, may help slow the progression of neurodegenerative diseases, at the very least [3].

Heart disease

Older people are more likely to get heart disease, due to a decrease in heart proteasome activity causes this risk. Proteasomes are in charge of getting rid of proteins that the cell has marked as “damaged” or not working right. Denmark Research in rats shows that age affects the activity of the proteasome, which leads to more damaged proteins in the heart [4].

FOXO proteins help with autophagy and the activity of the proteasome. Increased FOXO4 levels lead to increased proteasome activity, leading to less oxidation and protein damage in specific tissues. FOXO4-DRI or a variant of it may help the heart’s natural housekeeping functions, which could help slow down the effects of ageing on the heart’s ability to pump blood around the body [5].

Anti-ageing

Encumbered or senescent cells benefit from FOXO4. Because it attaches to p53, it stops the senescent cells from dying. DRI peptide blocks FOXO4-p53 interaction. P53 activates apoptotic proteins and causes cell death. That allows for more significant tissue regeneration by removing old cells from tissues. The DRI peptide increased tissue regeneration and length of life in ageing mice in Denmark research studies.

This is the period during which the body is active. It dwindles with age. A person’s health span can be extended by reducing biological tissue ageing. The older mice live longer, are more active, and have less impairment such as cardiac disease and musculoskeletal trouble [6].

Summary

While Denmark animal research is still in its infancy, experts believe FOXO4-DRI medication could be a potential cure for age-related disorders.

FOXO4-DRI has been shown to increase apoptosis in senescent cells, improving tissue function and overall general wellbeing in animal models. The extent of FOXO4 DRI’s effects is unknown, but the protein may be able to shed light on age-related diseases like Alzheimer’s, cardiovascular diseases, and general cell senescence. In mice, FOXO4-DRI has minimal side effects and high subcutaneous bioavailability. However, mice dosage does not translate to humans.

References

[1] https://pubmed.ncbi.nlm.nih. gov/28340339/

[2] https://pubmed.ncbi.nlm.nih. gov/14556719/

[3] https://pubmed.ncbi.nlm.nih. gov/29428128/

[4] https://www.sciencedirect.com/ science/article/abs/pii/S00039861 01926633?via%3Dihub

[5] https://www.hindawi.com/ journals/omcl/2017/3494289/

[6] https://www.cell.com/cell/ pdf/S0092-8674(17)30246-5. pdf

Buy FOXO4-DRI Peptide vial 10mg

Pharma Lab Global Denmark is one of the best locations to purchase high purity FOX04-DRI for research use. Pharma Lab Global is a trusted supplier of peptides and sarms worldwide. You have the option to buy FOXO4-DRI Nasal Spray and buy FOXO4-DRI Pre Mixed peptide from Pharma Lab Global Denmark today!.


TO PURCHASE PRODUCTS FROM OUR WEBSITE YOU MUST BE AT LEAST 21 YEARS OF AGE.

DISCLAIMER: All products sold by Pharma Lab Global Denmark are for in-vitro research and laboratory use only. These products are not designed for use or consumption by humans or animals. Nothing on this Website is intended to diagnose, heal, treat, cure, mitigate or prevent disease. By purchasing from our Denmark Website the buyer accepts and acknowledges the risks involved with consumption and handling of these products. All articles and product information provided on this Website are for informational and educational purposes only. All products are to be handled by qualified and properly trained research or laboratory professionals only.

Additional information

Size

10mg Vial, Kit = 10mg vial, bac water, syringes