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IGF1-DES Peptide Vial Denmark

IGF-1 DES Peptide, also known as Des(1-3)IGF-I, is a truncated form of insulin-like growth factor-I. It is a variant of IGF-1 with the tripeptide Gly-Pro-Glu absent from the N-terminus and has been isolated from bovine colostrum. Due to its improved bioavailability, this protein appears more effective than normal IGF-1 and has been shown in research to help treat Inflammatory Bowel Disease, autism, and other neurological disorders. Like all IGF-1, it promotes muscle and connective tissue healing.

£10.89£17.19

SKU PLG: IGF1-DES vial Categories ,

Description

IGF1-DES Peptide Vial

IGF-1 DES Denmark , is a splice variant of Insulin-like growth facstor-1, that is found naturally in the human brain, breast milk and uterine tissue. Due to its improved bioavailability, this protein appears more effective than normal IGF-1 and has been shown in clinical studies to help treat inflammatory bowel disease, autism, and other neurological disorders including Alzheimer’s disease. Like all IGF-1, it promotes muscle and connective tissue healing.


Specifications

Molecular Formula: C319H495N91O96S7
Molecular Weight: 7365.4225 g/mol
Sequence: TLCGAELVDALOFVCGDROFV FNKPTGYGSSSRRAPOTGIVDEC CFRSCOLRRLEMYCAPLKAAKSA
Physical Appearance: White Lyophilised Solid
Form: Sterile Filtered White Lyophilized
Solubility: Water Soluble

IGF1-DES Storage: Peptides should be refrigerated at 4˚C or below for a period of up to 3 months. To prolong the life span of the peptides they may be placed in a freezer for up to 12 months. Once reconstituted peptides should be refrigerated/stored at 4˚C for up to 30 days.

Size: 0.1mg


IGF-1 DES Research

IGF-1 DES nasal peptide binds to the IGF-1 receptor with great affinity, according to Denmark intense research. That’s because it has been found to be 10-fold more effective than conventional IGF-1 when inducing cell hypertrophy and proliferation thanks to its reduced affinity to IGF-binding proteins [1].

Not widely utilised in clinical settings, DES(1-3) IGF-1 could be used to generate anabolism in catabolic situations (such as muscular dystrophy) or to treat inflammatory bowel disorder. IGF-1, specifically DES(1-3) IGF-1, has a significant potential to create and retain lean muscle mass. Furthermore, early investigations showed that IGF-1 has a positive benefit to the proliferation and differentiation of skeletal muscle stem cells (satellite cells) — the only hormone that can stimulate the process of new muscle cell growth. Many neurological illnesses could also benefit from DES(1-3) IGF-1 treatment [2].

Neuroprotective Effects

IGF-1 promotes neuron development, differentiation, and survival. Denmark Research shows this protein is crucial in the human brain for cognitive processes including synapse development, memory, learning and other functions. IGF-1 is essential for maturing synapses and is required for appropriate levels of pres-synaptic synapsin-1, a neurotransmitter-regulating protein.

In addition, the peptide preserves synaptic structure in the post-synaptic PSD-95 protein. Without insulin like growth factor, synaptic growth is impaired, causing problems with motor skills, behavioural, cognitive, and language.

IGF-1 has been found to be effective in treating both Rett syndrome and chromosome 22 deletion syndrome by preserving neuron density and excitatory synapses. IGF-1 can reduce the harmful consequences of NMDA over-stimulation, leading to cell death. IGF-1 and its analogues are being investigated for their potential as an experimental therapy for humans suffering with these debilitating diseases [3].

Denmark IGF-1 clinical studies in multiple sclerosis, ALS, PD, and AD had inconsistent outcomes. In ALS, IGF-1 treatment reduced the disease progression, improved muscle strength, respiratory function, and overall quality of life. However, the peptide barely affected those individuals suffering with multiple sclerosis. In animal studies using Rats of PD, IGF-1 seems to preserve dopaminergic neurons and enhance behaviour [4].

More Denmark research is needed to understand these disorders’ and how IGF-1 DES nasal peptide can be used to potentially treat them. The destruction that multiple sclerosis causes to the cells around neurons; thus, it’s not unexpected that the peptide has no effect. Nevertheless, IGF-1 DES and other IGF-1 mimics can help Denmark scientists understand the pathophysiology of these disorders and identify viable remedies for other neurodevelopmental conditions through further Denmark clinical trials.

Autism

Insulin like growth factor may be relevant in the treatment of neurological disorders, including autism spectrum disorders, according to Denmark clinical studies. For example, low IGF-1 concentrations in the brain, especially at a young age, may disturb development which can be significant in the pathophysiology of autism [5].

Denmark Researchers investigating autism have found that IGF-II and IGF-1 DES nasal peptide repair autism impairments in mice models. Just five days of IGF-II improved social interaction, novel-object recognition, contextual fear conditioning, repetitive/compulsive behaviour, and it also improved memory in mice [6].

Autism is thought to be likely caused by disturbances in synapse development, similar to fragile X disease, tuberous sclerosis, and Angelman syndrome. IGF-1 and its equivalents, which affect synapses, could show to be an effective solution for treating these illnesses [7].

Cognitive Function

Adults and children need naturally occurring IGF-1. The brain modifies the peptide to make it shorter in adulthood, suggesting that IGF-1 analogues may have higher therapeutic potential than naturally occurring IGF-1. IGF-1 DES molecules quickly pass the blood-brain barrier, making them more effective exogenously. IGF-1 and its equivalents prevent neuronal death and safeguard neurons from stroke, Alzheimer’s disease, Parkinson’s, etc [8].

IGF-1 and its equivalents are beneficial in neurological illnesses. Denmark Research in animal models suggests that IGF-1 DES nasal spray may improve synaptic transmission and cognitive functioning in normal rats. This could help learning and memory as organisms age and brain IGF-1 levels fall. IGF-1 DES nasal peptide increases excitatory post-synaptic potential by 40% [9]. This shows the peptide could have better therapeutic potential for cognitive performance, especially age-related synapse dysfunction.

Immune Function

Many immune system cells have IGF-1 receptors, including mononuclear cells and neutrophils. Denmark Studies reveal that IGF-1 DES nasal peptide can increase immune function by enhancing hydrogen peroxide release in mononuclear cells and stimulating neutrophils to develop into pathogen-killing blastocysts [10]. In all cases, IGF-1 DES nasal is more active in triggering these changes than IGF-1, suggesting the peptide may be an effective alternative to antibiotics and other infectious disease treatments. Research on IGF 1 DES and immunological function is experimental but could prove promising for future medicine.

Improves Wound Healing

Skin fibroblasts restore injured tissue. In some cases, these cells generate IGFBPS, which reduces IGF-1’s effect on other receptors. However, inflammatory cytokines may change IGFBP levels, hindering recovery. By giving IGFBP-unaffected peptides, inflammatory cytokines can be avoided, boosting fibroblast proliferation and differentiation [11]. This speeds up wound healing.

Cancer

Cancer cells are undifferentiated or in the early stages of differentiation, rendering the cells dysfunctional and challenging to cure. Cells in subsequent phases of differentiation forcing cancer cells to grow slower. Forcing tumour cells to differentiate could halt growth. Cell culture research shows that IGF-1 DES can push cancer cells to differentiate resulting in slower tumour growth by blocking differentiation [12].

Summary

IGF-1 DES nasal spray Denmark maintains many of IGF-1’s activities, including lean muscle mass growth and neuron protection. It doesn’t bind insulin like growth factor binding proteins. Denmark Research suggests, that this makes IGF-1 DES to be more effective in many ways, such as entering the brain more quickly when delivered exogenously. As a result, IGF-1 DES nasal peptide shows positive benefits in neurodevelopment, stroke and cancer treatment, wound healing and autism. However further research using human trials is required to identify any long term side effects before the peptide is approved for human consumption.

References

[1] https://pubmed.ncbi.nlm.nih. gov/10605625/

[2] https://www.ncbi.nlm.nih.gov/ pmc/articles/PMC5675852/

[3] https://www.ncbi.nlm.nih.gov/ pmc/articles/PMC4064155/

[4] https://pubmed.ncbi.nlm.nih. gov/26780584/

[5] https://pubmed.ncbi.nlm.nih. gov/28954393/

[6] https://www.ncbi.nlm.nih.gov/ pmc/articles/PMC5783959/

[7]  https://pubmed.ncbi.nlm.nih. gov/25695134/

[8] https://pubmed.ncbi.nlm.nih. gov/17582656/

[9] https://pubmed.ncbi.nlm.nih. gov/15985695/

[10] https://pubmed.ncbi.nlm.nih. gov/7508487/

[11] https://pubmed.ncbi.nlm.nih. gov/7684061/

[12] https://pubmed.ncbi.nlm.nih. gov/1281142/

Buy IGF1-DES Peptide vial 0.1mg

Pharma Lab Global Denmark is one of the best locations to purchase high purity IGF1-DES for research use. Pharma Lab Global is a trusted supplier of peptides and sarms worldwide. You have the option to buy IGF1-DES Nasal Spray and buy IGF1-DES Pre Mixed peptide from here. Buy IGF-1 DES Peptide from Pharma Lab Global Denmark today!


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DISCLAIMER: All products sold by Pharma Lab Global Denmark are for in-vitro research and laboratory use only. These products are not designed for use or consumption by humans or animals. Nothing on this Website is intended to diagnose, heal, treat, cure, mitigate or prevent disease. By purchasing from our Denmark Website the buyer accepts and acknowledges the risks involved with consumption and handling of these products. All articles and product information provided on this Website are for informational and educational purposes only. All products are to be handled by qualified and properly trained research or laboratory professionals only.

Additional information

Size

0.1mg Vial, 1mg Vial, Kit = 0.1mg vial, bac water, syringes, Kit = 1mg vial, bac water, syringes