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LL-37 Cap-18 Peptide Vial Denmark

LL-37 Cap-18 is an antiseptic agent that can be used to treat fungal infections and serious bacterial infections. It has proved to be useful against skin infections, particularly in cases where the disease is resistant to most anti-fungal agents. In addition, it has also shown promise in fighting against bacterial skin infections due to fungal causes, such as candida albicans.

£37.43£44.23

SKU PLG: LL-37 vial Categories ,

Description

LL-37 (Cap-18) Peptide Vial 5mg

Scientific research have shown that LL-37 Cap-18 is an antibacterial protein that can be used to treat fungal infections and bacterial infections. It has proved to be useful against bacterial skin infections, particularly in cases where the disease is resistant to most anti-fungal agents. In addition, it has also shown promise in fighting against bacterial skin infections due to fungal causes, such as candida albicans. Recently, researchers have been studying the peptide LL-37’s benefits for cathelicidic dermatitis and how this substance can benefit people with this chronic skin disorder.

LL-37 can be used to treat cathelicidic dermatitis as this substance has proved effective in reducing the inflammation caused by this condition. This Peptide works by inhibiting the production of proinflammatory cytokines, which is one of the main causes of inflammation that can be attributed to cathelicidic dermatitis. As a result, it helps to eliminate the yeast and bacteria that cause cathelicidic skin disorder, thus relieving the symptoms associated with the condition.


Specifications

Molecular Formula: C205H340N60O53
Sequence: H-Leu-Leu-Gly-Asp-Phe-Phe-Arg-Lys-Ser-Lys-Glu-Lys-Ile-Gly-Lys-Glu-Phe-Lys-Arg-Ile-Val-Gln-Arg-Ile-Lys-Asp-Phe-Leu-Arg-Asn-Leu-Val-Pro-Arg-Thr-Glu-Ser-OH
Molecular Weight: 4493 g/mol
Physical Appearance: White Lyophilised Solid
Form: Sterile Filtered White Lyophilized
Solubility: Water Soluble

LL-37 Storage: -20˚C

Size: 5mg


LL-37 Research

Antimicrobial

As an immune system component, LL-37 is considered a antimicrobial peptide andoperates by adhering to and interfering with bacterial lipopolysaccharide (LPS), a critical component of gram-negative bacteria. Additionally, it inhibits the growth of gram-positive bacteria, making it effective against staph infections and other bacterial-related disorders [1].

According to Denmark studies on skin infections, normal skin has minimal levels of LL-37, but it rapidly accumulates when pathogens penetrate the body. Additionally, as seen in animal experiments, this peptide functions well with other proteins such as mice beta-defensin 2 to defeat the infection [2].

Tissue repair

LL-37 cap-18 peptide is antibacterial and controls the balance of pro- and anti-inflammatory chemicals in mice. However, scientists say it’s tough to balance inflammation and tissue recovery. Because while inflammatory reactions assist the body fight invaders, they can also obstruct healing, induce scar tissue formation, and even trigger autoimmune illnesses. Denmark Clinical studies have found that LL-37 therapy has the ability to balance inflammation, aid wound closure and healing by affecting macrophages, which plays an important role in the cause of inflammation when infections penetrate the body [3].

When macrophages recognize pathogens, they alert the rest of the body to defend. Next, the immune system destroys the infections, while macrophages produce new signals to lower inflammation. According to animal studies, LL-37 cathelicidin peptide reverses macrophage activation, turning anti-inflammatory macrophages pro-inflammatory.

LL-37 also inhibits biofilm formation, which can help heal wounds caused by P. aeruginosa and Staph infections. In addition, as shown in Denmark  animal studies, it can kill bacteria and promote wound healing by interacting with fibroblasts and keratinocytes [2].

Inflammatory Diseases

LL37 is primarily an antibacterial peptide, but it also helps inflammatory illnesses and autoimmune diseases like lupus, arthritis, and psoriasis. Ll-37 modulates the immune system by decreasing apoptotic keratinocytes, enhancing IL-18 and IFN-alpha generation, modifying neutrophils, and reducing atherosclerotic plaque levels.

The immune system isn’t always affected in the same manner by LL-37/CAP-18. In some circumstances, inactivated T-cells respond to the peptide by increasing their inflammatory activity, while activated T-cells decrease it.

Further Denmark research shows that LL 37 Cap-18 has homeostatic benefits, maintaining immune system regulation and reducing the danger of infection-induced over activity.

Experts believe LL-37 Cap-18 could help control autoimmune inflammation. New research shows it may be a therapy for autoimmune disease [4].

Arthritis

LL-37 cap-18 has been shown to help arthritis because of it’s ability to reduce inflammation. During experiments the synthetic peptide was administered into arthritic joints of rats with great success [5].

Another study on mice found that LL-37 Cap-18 protects against collagen damage caused by inflammatory arthritis [6]. Direct application of LL-37 to afflicted joints can reduce disease severity. Because LL 37 is abundant in inflamed tissues, scientists assume it has anti-arthritic properties. The peptide also appears to regulate interleukin-32, a molecule linked to arthritis.

There’s additional evidence that toll-like receptor 3 activation exacerbates arthritic symptoms. By binding to TLR4, it can produce anti-inflammatory actions [7].

Lung Disease

LPS has been detected in several species in clinical trials. When inhaled, this chemical stimulates healthy lung tissue. However, it does not treat respiratory diseases like asthma or COPD. The peptide LL-37 may help treat toxic dust syndrome [8].

According to research findings on LL-37 peptide and lung illness, the peptide enhances epithelial cell proliferation and tissue repair. In addition, drawing pulmonary epithelial cells to the injury site encourages the formation of blood vessels that nourish and maintain the new tissue [9].

Intestinal Cancer

Studies reveal that the LL-37 peptide may help with stomach and intestinal cancers by reducing intestinal inflammation. While the investigation is currently limited, vitamin D exposure has anti-cancer properties [10].

Summary

Due to its versatile and beneficial properties, LL-37 Cap 18 peptide holds promise for various therapeutic applications, including infectious diseases, wound healing treatments, and even potential applications in dermatology and cancer therapy. Ongoing research continues to explore its potential in these areas.

References

[1] https://pubmed.ncbi.nlm.nih.gov/ 15980359/

[2] https://pubmed.ncbi.nlm.nih.gov/ 15963694/

[3] https://pubmed.ncbi.nlm.nih.gov/ 24185823/

[4] https://pubmed.ncbi.nlm.nih.gov/ 30372860/

[5] https://www.ncbi.nlm.nih.gov/ pmc/articles/PMC4137957/

[6] https://pubmed.ncbi.nlm.nih.gov/ 24091294/

[7] https://pubmed.ncbi.nlm.nih.gov/ 21708001/

[8] https://pubmed.ncbi.nlm.nih.gov/ 17655171/

[9] https://pubmed.ncbi.nlm.nih.gov/ 15964896/

[10] https://pubmed.ncbi.nlm.nih.gov/ 29843147/

Buy LL-37 Cap-18 Peptide Vial 5mg

Pharma Lab Global Denmark is one of the best locations to purchase high purity LL-37 Cap-18 for research use. Pharma Lab Global is a trusted supplier of peptides and sarms worldwide. You have the option to buy LL-37 Cap-18 Nasal Spray and buy LL-37 Cap-18 Pre Mixed peptide. Buy LL-37 (Cap-18) Peptide from Pharma Lab Global Denmark today!


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DISCLAIMER: All products sold by PharmaLabGlobal Denmark are for in-vitro research and laboratory use only. These products are not designed for use or consumption by humans or animals. Nothing on this Website is intended to diagnose, heal, treat, cure, mitigate or prevent disease. By purchasing from our Denmark Website the buyer accepts and acknowledges the risks involved with consumption and handling of these products. All articles and product information provided on this Website are for informational and educational purposes only. All products are to be handled by qualified and properly trained research or laboratory professionals only.

Additional information

Weight 0.1 kg
Dimensions 1 × 1 × 1 cm
Size

5mg Vial, Kit = 5mg vial, bac water, syringes