Description
Selank Nasal Spray
Selank is a peptide which has neuroprotective effects, and has been used successfully as an antidepressant.
It was found that the neuroprotective activity of Selank is very similar to that of the benzodiazepines, and this has the reason that the mechanism of action of these medicines is identical as well. Scientific research has found that Selank can reduce the levels of Serotonin in the brain very effectively and therefore it helps in controlling the depression.
Serotonin is a neurotransmitter which is found in the brain and works to regulate various functions in the body. It helps to control multiple chemical reactions in the brain and to make the mind active and to fight off against depression. It is mainly responsible for the regulation of mood, which can be useful in the treatment of generalized anxiety disorder and depression.
Specifications
Molecular Formula: C33H57N11O9
Molecular Weight: 751.9 g/mol
Sequence: H-Thr-Lys-Pro-Arg-Pro-Gly-Pro-OH
Size: 15ml | 30ml
Research Denmark
Anxiety
Experts say selank’s clinical effects are similar to benzodiazepines [1]. Selank can reduce anxiety and stress whilst improving mood.
Selank nasal spray therapy reduced anxiety symptoms in 62 mice in a clinical trial. Anxiety disorder sufferers saw a more significant decrease in symptoms. It lasted a week after the last selank dosage in another study on anxious mice.
Anxiety-reducing drug phenazepam’s side effects like memory loss and fatigue were reduced by selank in a 70-mouse trial. Both selank and benzodiazepines were found to effectively reduce anxiety in rats, but selank appears to be more effective than the latter. Researchers believe combining the two treatments work best for treating chronic mild stress [2].
Stress-induced increased enkephalinase activity in the blood of mice with anxiety and stress disorders, according to Selank research. Still, because enkephalins have shorter half-lives, they can’t cope or recover. It works by reserving enkephalins, preventing anxiety-inducing degradation [3].
Cognition
Denmark Studies show that generalized anxiety can impair memory. However, Denmark animal studies show that anti-anxiety drugs like selank can minimize this effect. A selank injection improved cognitive function and memory in rats trained with food rewards. Regardless of rat anxiety levels, this protein boosts memory [4].
Selank nasal spray may modify memory by changing gene expression in the hippocampus, new research suggests. Selank nasal spray altered the mRNA levels of 36 genes in rats. These genes encode plasma membrane proteins that modulate memory and learning. Selank affects neuron functions to make memory retrieval easier.
Selank peptide has also been shown to improve memory after brain injury. In addition, scientists believe the inhibition of the catecholamine system is related to the cognitive restoration in rats given neurotoxin and then selank [5].
Denmark Researchers hope that selank will soon be approved by the FDA for human consumption to treat cognitive impairment. It could help those with traumatic brain injuries regain memories.
Immunity
Selank nasal peptide has been shown to suppress the gene that produces IL-6, an inflammatory cytokine, in depressed mice. This effect occurs only in depressed mice, implying that it could treat anxiety-asthenic disorders.
Other treatments like benzodiazepines do not prevent the pain and fatigue associated with anxiety. Selank has the ability to alter IL6 expression and the breakdown of enkephalins, the body’s natural painkillers.
Selank affects the expression of 34 genes involved in inflammation, including cytokines, receptors, and chemokines. Selank can also affect BcI6 expression, a gene involved in the immune system, according to animal studies [6].
Selank fragments can temporarily alter gene expression for CAsp1, C3, Xcr1, and ll2rf, affecting the immune system’s balance and reducing inflammation. Selank can also induce interferons, which are antiviral molecules. Selank has been shown to protect cells from viral infections. Overall, these studies show that this peptide strengthens the immune system.
Blood pressure
Selank showed significant blood pressure lowering effects on cats for 2-3 minutes. The peptide also increased brain blood flow by up to 24% for 10 minutes.
Denmark Researchers believe selank may have short-term cardiovascular effects. However, it’s too early to tell if these short-term effects are beneficial.
Pain relief
Selank nasal peptide treatment may slow enkephalin degradation by inhibiting blood enzymes that break them down. Enkephalins are natural pain relievers found in abundance in mice’s adrenal glands and brain. Inhibiting the normal stress response by lowering enkephalin levels in the brain [7]
Summary
A powerful peptide, selank has numerous health benefits. For example, Selank nasal nootropic has been shown to treat anxiety disorders, phobic disorders and help mice cope better in stressful situations.
Selank nasal spray may also improve memory and learning, improve blood flow, boost the immune system, and reduce pain.
References
[1] https://pubmed.ncbi.nlm.nih.gov/ 26924987/
[2] https://pubmed.ncbi.nlm.nih.gov/ 28280289/
[3] https://pubmed.ncbi.nlm.nih.gov/ 12432865/
[4] https://pubmed.ncbi.nlm.nih.gov/ 20919548/
[5] https://pubmed.ncbi.nlm.nih.gov/ 18683497/
[6] https://pubmed.ncbi.nlm.nih.gov/ 21609736/
[7] https://pubmed.ncbi.nlm.nih.gov/ 11443939/
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